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This adjustment is important for effectiveness, since higher doses are associated with greater weight loss results in clinical trials
The NO-system modulation by BPC-157 raises a pharmacodynamic concern with non-selective beta-blockers such as propranolol and nadolol, which are prescribed for variceal bleeding prophylaxis [2]
Moreover, elevated systemic concentrations of TMAO enhanced thrombosis potential in vivo in animal models (4), and in recent clinical intervention studies, elevation in plasma TMAO induced with dietary choline supplementation altered platelet hyperresponsiveness in subjects (omnivores and vegans/vegetarians alike), as monitored by platelet aggregometry (17)
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