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While adipose tissue (fat) is the preferred source, the body will also break down skeletal muscle for amino acids if specific preservation signalsnamely dietary protein and mechanical stressare absent
Muscle is your calorie-burning engine
Understanding your genetic predispositionssuch as variations in GLP1R rs6923761 or FTO rs9939609can help explain your individual appetite suppression profile and guide whether a timing adjustment might affect your results
These findings came from the 2023 phase 2 clinical trial of retatrutide published in the New England Journal of Medicine, which observed dose-dependent weight loss across multiple dose levels
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