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Figure 2 2 Data of efficacy 2.1 Clinical trials: the SURPASS program The central clinical trial program designed to demonstrate the therapeutic effectiveness (in terms of GC and BW reduction), tolerability and safety of TZP in diabetic patients was the SURPASS program
This mechanism complements the angiogenic and proliferative effects of the peptide, ensuring that new cells not only form but also reach the locations where they are needed
If this signified reduced cellular energy generation, it would contradict the notion that the other enzymatic changes were favorable
And importantly, skeletal muscle does not appear to have a functional GLP-1 receptor, meaning these molecular effects are being mediated through indirect signaling pathways that we do not yet fully understand
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