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Biological characteristics of GLP-1RAs Molecular structure and pharmacological properties Due to the suboptimal in vivo stability of the native GLP-1 peptide, GLP-1RAs were engineered with structural modifications that mimic endogenous GLP-1 while achieving a prolonged duration of action [15]

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XPP treatment significantly reduced IL-4 levels and increased IL-4 promoter methylation, without affecting IgG, IgA, or IFN- production [64]

Regular follow-up appointments, typically scheduled every 4 to 12 weeks during the initial treatment phase, allow for dose adjustments, side effect management, and monitoring of therapeutic outcomes