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As a naturally occurring substance in the body, it is generally safe to use
Methylcobalamin is preferred over cyanocobalamin (the synthetic form) in many clinical settings because it is the metabolically active coenzyme form of B12, meaning the body can utilise it immediately without further conversion
A sister trial (STEP-HFpEF DM) is evaluating the effects of semaglutide in patients with obesity phenotype of HFpEF and diabetes (NCT04916470)
By comparing both analyses, we can distinguish general prescribing trends from those specific to adolescents with obesity, helping to contextualize the extent to which these medications are used in alignment with clinical guidelines
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