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Description Glutathione is the master antioxidant in the body and is heavily concentrated in tissues such as the liver, spleen, and heart
KoschinskyTHeCJMitsuhashiTBucalaRLiuCBuentingCet al
Methyl-deficient diet promotes colitis and SIRT1-mediated endoplasmic reticulum stress
Given that EtOH-induced mitochondrial dysfunction and ER stress are intimately involved in the pathogenesis of ALD, future studies to examine these pathways under the current experimental setting will provide important mechanistic information underlying the protection seen in GCLM KO mice
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