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Nausea and vomiting was the most common side effect, with the worst five antidepressants being duloxetine (odds ratio [OR] 4.33), vortioxetine (OR 4.28), levomilnacipran (OR 3.81), venlafaxine (OR 3.52), and desvenlafaxine (OR 3.51)

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) present an important new treatment option for patients with obesity, and act primarily by decreasing caloric intake through appetite suppression

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