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Article contents Abstract Introduction Sarcopenia: definition, prevalence and mechanisms Prevalence of paracetamol treatment in older individuals Paracetamol detoxification induces an irreversible loss of cyseine Cysteine, a conditionally indispensable amino acid Effects of long-term paracetamol treatment on glutathione and cysteine homeostasis Effects of long-term paracetamol treatment on skeletal muscle Nutritional implications of paracetamol treatment Conclusion References Impact of medication on protein and amino acid metabolism in the elderly: the sulfur amino acid and paracetamol case Published online by Cambridge University Press: 20 March 2018 Abstract Introduction Sarcopenia: definition, prevalence and mechanisms Prevalence of paracetamol treatment in older individuals Paracetamol detoxification induces an irreversible loss of cyseine Cysteine, a conditionally indispensable amino acid Effects of long-term paracetamol treatment on glutathione and cysteine homeostasis Effects of long-term paracetamol treatment on skeletal muscle Nutritional implications of paracetamol treatment Conclusion References Abstract The optimisation of nutritional support for the growing number of older individuals does not usually take into account medication