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If you experience persistent hunger while on semaglutide, here are a few reasons why you might still feel hungry when using semaglutide: Hunger wont completely disappear While semaglutide makes you feel less hungry, it will not make you ever feel hungry
When insulin sensitivity drops: GLP-1 signaling becomes less effective The body may produce less GLP-1 Tissues respond less to the GLP-1 that is available This creates a metabolic feedback loop that can worsen blood sugar control over time
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doi: 10.1111/acel.12054 32 SwansonCJZhangYDhaddaSWangJKaplowJLaiRYKet al
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