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NICE Clinical Knowledge Summary (CKS) and NHS guidance emphasise the importance of addressing both reproductive and metabolic aspects of PCOS through lifestyle modification, pharmacological intervention when appropriate, and regular screening for associated comorbidities, including periodic HbA1c or glucose tolerance testing and lipid monitoring

when we talk about GLP-1 in this context, we usually mean the direct receptor agonist drugs such as those listed above

Retatrutide is marginally more likely to cause each listed side effect, but we are talking 1 to 3 percentage point gaps across the board

102,103 Albiglutide is a long-acting GLP-1RA injected subcutaneously once a week