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Dual inhibition of SGLT2 and DPP-4 highly promotes a distal tubular sodium delivery and thereby contributes to the appropriate modulation of preglomerular arteriolar tone and intraglomerular pressure via an increase in adenosine release and a reduction in PGE2 secretion from macula densa during DKD (150)

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Weight regain during the one-year post-treatment phase was 6 kg larger for participants who had previously received liraglutide alone than participants who had previously received supervised exercise alone, despite similar initial weight loss

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