The results showed that after FOXO4-DRI treatment, the p-P53/P53 ratio significantly increased in the nucleus, cytoplasm, and total protein samples (Figure 5D)
In addition, a variety of synthetic compounds with in vitro antioxidant activity have been developed to treat diseases, including recombinant SOD, catalase, nitroxyl radicals, iron ion chelators, deuterated PUFAs, thiols, and ROS-generating enzyme inhibitors
Interestingly, LPC remyelination DAMs remained enriched for inflammatory genes ( Il1b, Cxcl9, Cd69 ), complement components ( C1qa, C3 ), and hypoxia/glycolysis-associated genes ( Mt1 , Slc2a1 ), suggesting a continued pro-inflammatory microglial state during LPC remyelination stages (Fig
Taurine Amino sulfonic acid involved in calcium handling, membrane stabilization, and bile conjugation