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As alluded to above, the rationale for combining GLP-1R agonism with either GIPR agonism or antagonism is, however, still debated, and how the GIPR agonistic properties of tirzepatide contribute to body-weight loss remains unclear [19]
[5] [6] Similarly, individuals with pre-existing fatigue, anaemia, or other comorbidities may find that GLP-1 therapy temporarily exacerbates their symptoms
For most people it is mild to moderate and improves over the following weeks
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