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Consoli A, Formoso G, Baldassarre MPA, et al

[1] [4] Alterations in GLP-1 function may involve reduced production of the hormone or impaired secretion in response to meals

Research backs this up: when using GLP-1s to aid in weight loss, they were found to effectively reduce BMI, triglycerides, waist circumference, and total testosterone in people with PCOS, according to a 2024 meta-analysis in the Journal of Diabetes and its Complications

Also, a recent systematic review indicates that tirzepatide treatment in adults is associated with reductions in fat mass, relative preservation of lean mass, and decreases in MFI [69], all of which are critical for sarcopenia risk and functional capacity