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The gap between doing this work correctly and wasting months of effort comes down to understanding what the evidence base actually contains versus what supplement marketing claims it contains

Infertility can also occur in individuals with insufficient B12

16 Sleep studies that include electroencephalogram (EEG, brain electrical wave monitoring) have shown fibromyalgia patients experience shorter sleep duration, more awakenings during sleep, longer light sleep phases, and shorter deep restorative sleep phases

The overall risk appears to be very low, but the theoretical concern necessitates appropriate patient selection and informed consent