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13 HAPE, a noncardiogenic pulmonary edema and the most fatal form of acute altitude illness, is characterized by dyspnea, loss of stamina, and dry cough, followed by dyspnea at rest, cyanosis, gurgling in the chest and pink frothy sputum
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This leads to NF-B-mediated expression of pro-inflammatory cytokines (IL-6 and TNF-), constituting a core mechanism of acute gout attacks
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