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The research is inconclusive regarding whether vitamin C reduces the chance of developing cancer, prevents heart disease, prevents eye disease such as macular degeneration, or prevents the common cold

Options for managing tolerance include a brief dose reduction for 4 to 8 weeks ("drug holiday" at a lower dose, not complete cessation), lifestyle optimization to maximize the medication effect, evaluation for other contributing factors (thyroid function, cortisol, sleep quality, medication interactions), and consideration of adding a complementary compound to address specific aspects of the plateau

Off-the-shelf platforms handle the easy 10%

Ormerod, R