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Lipids, especially polyunsaturated fatty acids (PUFAs) in membrane phospholipids, are prime targets for ROS-induced peroxidation (Gentile et al., 2021)

Possible process of compromised immunotolerance in women is asymmetrical X chromosome inactivation (XCI), which cause evade from the presentation of X-linked self-antigens in the thymus and following deterioration of T cell tolerance