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The good news: the 9mg dose appears to offer a reasonable compromise 25.926.4% weight loss with only 8.8% dysesthesia incidence
Its the same drug performing double duty under two different brand names with two different FDA indications
40 Preclinical studies have shown that these effects are mainly mediated trough the effects of GLP-1R activation in the central nervous system (CNS) by the modulation of orexigenic and anorexigenic signaling pathways
This effect appears to be driven by anti-inflammatory and proliferative mechanisms independent of receptor activation/signaling in the resident vascular cells [74,75,76]
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