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The Kraus 2014 Nature paper established that NNMT is highly expressed in adipose tissue (especially in obesity) and that NNMT knockdown in adipose protects against diet-induced obesity in mice

A deficiency in Vitamin B12 leads to inefficient use of energy, making it more difficult to do physical activities for weight loss

Flexible for Every Lifestyle Whether youre a busy professional, an athlete, or someone focused on preventive care, B-12 injections fit easily into your schedule

But for most purposes (like weekly maintenance injections), IM is the preferred route at home because its simpler (the vitamins absorb quickly from muscle into the bloodstream over a few hours)