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GLP-1R activation has a significant effect on glycemic control in patients with T2DM through a variety of mechanisms, including stimulation of insulin secretion, inhibition of glucagon secretion, protection of -cells from apoptosis, slowing gastric emptying and increasing satiety (Drucker, 2006)
L., & Mrquez, J
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The loading phase builds tissue concentration over 4 to 6 weeks, after which maintenance dosing preserves benefits with reduced frequency
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