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In vitro studies, although useful for clarifying molecular pathways as NF-B suppression, antioxidant enzyme overexpression, sometimes employ elevated, non-physiological concentrations of extracts and may fail to correctly simulate the complex context of the human eye

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One year post-discontinuation, 35.2% of patients (2,794) received an alternative obesity treatment: 27.4% received another medication, 13.7% received modifications and visits with a health care professional, and 0.6% received metabolic or bariatric surgery