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The EM structure of Tirzepatide bound to the complete GLP-1R and G-proteins (Figure 2, PDB ID 7rgp , Sun et al., 2022) shows some hydrophobic and some specific polar interactions between the peptidic drug and the GLP-1 receptor molecule

The burgeoning connection between GLP-1 use and eating disorders raises more questions about who might be a good fit for the medication and how clinicians can best support patients as they work through improvements or declines in their relationship with food

Add that to a GLP-1 prescription and you have a recipe for success