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Therefore, while efforts undoubtedly need to be intensified towards preventing the onset of the disease and making lifestyle modifications (a fundamental aspect of the therapy for every patient with T2DM), it is clear, as indicated by the most recent guidelines [78], that the pharmacological approach should focus on timely treatment that leaves no room for therapeutic inertia and employs medications that are as effective as possible in both metabolic control and the prevention of chronic complications
The Breslow thickness is the single most important local prognostic factor in primary melanoma, as thicker melanomas are more likely to metastasise (spread)
Oct 2013;126:118-24
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