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The weight loss element comes from slower digestion
What they found: Oral AOD-9604 reduced body fat by 18 to 22 % vs placebo, comparable to injection administration No changes in total body weight (because lean mass rose slightly) Decrease in plasma triglycerides by 30 % Decrease in resting free fatty acids (paradoxically, mobilization of fat from depots into oxidation) No GI side effects Why it matters: It suggested that AOD-9604 could work orally , a rare property for a peptide
MOTS-c influences multiple areas of health
257,258 On the other hand, stimulation of GLP-1R in the kidneys and cardiovascular system may enhance renal function, lower blood pressure, and promote vasodilation
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