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Contrary t o this study, however, the mitochondrial genome sequencing of 400 proband-father pairs found no evidence of a link between mtDNA mutations and ASD [88]

The classical pyroptosis pathway is triggered by pathogen-associated molecular patterns (PAMPs) or damage-associated molecular patterns (DAMPs) recognized by specific receptors (Frank and Vince, 2019), leads to the assembly of inflammasomes, which then recruit and activate caspase-1, a key executioner protein in pyroptosis

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