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This conformational restriction prevents the peptide from adopting flexible substrate orientations that proteases require for efficient cleavage

It means precision matters more outside controlled environments

After the impact, the influx of Ca 2+ ions into the cell cytoplasm leads to the phosphorylation/activation of phospholipases that cleave phospholipids into fatty acids, diaglycerols and lysophospholipids like LPC, which initiates signaling cascades that drive inflammation, BBB destruction, demyelination, and protein aggregation in several neurodegenerative contexts [81]

Garber AL, Abrahamson MJ, Barziley JI, Blonde L, Bloomgarden ZT, Bush MA, et al