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Green et al 26 Severe clinical abnormalities should be treated intensively with B 12 , cyanoB 12 or hydroxyB 12 : HydroxyB 12 is commonly used in Europe, often at intervals of 23 months, as it seems to have better retention than cyanoB 12
The process of freeze-drying (lyophilization) removes water, making them stable for shipping and storage
Meanwhile: Systemic reviews still note that trailed human data are sparse, and most benefits remain in the preclinical promise category
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