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For instance, enhanced reduction of selenite and accelerated trans-selenation pathway for SeMet [analog of trans-sulfuration mechanism, transferring sulfur from methionine to serine to yield cysteine (Jackson et al., 2013)] may be additional sources of Se for selenophospate synthesis and consequently selenoprotein production (Seale, 2019)

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Thus, the concept of neuroprogression explains the clinical symptoms well, but it is still not sufficient to know whether all these changes are the cause or a consequence of the disease

3 Se supplementation in critically ill conditions Concerning the antioxidative and anti-inflammatory role of Se, promising findings have been reported with Se supplementation in critical illness