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SGLT-2 inhibitors are superior to GLP-1 receptor agonists in improving cardiovascular and renal outcomes, except for nonfatal stroke
Tirzepatide lowers blood pressure through weight loss and reduced sympathetic nervous system activation
It does mean that confident claims about outcomes in human patients are not supported by the current evidence base
Simon, A., Monier, F., Emonard, H., Gillery, P., Birembaut, P., Hornebeck, W., & Maquart, F
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