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While real-world data on the level of adherence to dual GLP1-RA/GIP agonists are not available to date, some considerations can be drawn from available clinical trials and experiences with other pharmacological classes

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GLP-1 receptor agonists also have effects on inflammation and immunity, both of which can contribute to reduction in colorectal cancer risk. Researchers observed no other statistically significant associations with GLP-1 use, nor did they see any statistically significant adverse associations with any cancer type

Given the high cost of GLP-1s, the patients in that arm of the study may also have had greater access to resources (exercise programs, health coaches, and nutritionists), she says