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As a transcription target of p53, the activity of spermidine/spermine N 1 -acetyltransferase 1 (SAT1), the rate-limiting enzyme in polyamine catabolism, induces lipid peroxidation and sensitizes cells to undergo ferroptosis and the deletion of SAT1 suppresses p53 and p53 3 KR -mediated ferroptosis
Others : hypoglycemia, weight loss
They are currently only approved for managing Type 2 Diabetes Mellitus among the adult population in the USA
However, anecdotal reports and the complex interplay between metabolic changes, weight loss, and underlying diabetes warrant careful consideration
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