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The STEP trials (20212023) demonstrated that semaglutide produces 1522% body-weight loss over 68 weeks when combined with lifestyle changes, compared to 23% weight loss with placebo
Metabolic inflammation, characterized by elevated IL-6 in the lungs and circulation has been linked to worsened asthma severity in individuals with obesity, independently of body mass index (BMI) [51]
a 2025 IV pilot in two adults used 10 mg and 20 mg single infusions and reported no adverse effects (Lee et al., Alternative Therapies in Health and Medicine)
Methadone, first approved in 1972 for OUD, was the first major step forward
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