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Supraphysiological doses of intravenous PYY3-36 cause nausea, but no additional reduction in food intake
The same endpoint was available for the glycemic efficacy trials (SUSTAIN 15, the two SUSTAIN Japanese trials, and PIONEER 15 and 710)
Because your body does not readily store excess amounts, toxicity from B12 is very unlikely, even at the higher doses used in injections
The brain begins interpreting normal stimuli as painful
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