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From a basic science standpoint, acetylcysteine neutralizes NAPQI in a 1:1 molar ratio, so the dose of acetylcysteine should be scaled up in proportion to the amount of acetaminophen
However, jumping ahead in the dosing schedule is generally discouraged by medical professionals
Generally, you need a BMI of 30 or higher, or a BMI of 27 or higher with at least one weight-related health condition like type 2 diabetes, high blood pressure, or high cholesterol
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