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Finally, standardization of polyphenol preparations (e.g., percentage of trans-resveratrol, curcumin 95%) was inconsistently reported across studies, limiting cross-study comparability

However, as part of the natural aging process, NAD+ levels decline, which can adversely affect cellular function and general health

For testing the difference in mean and median lifespan between groups, we used linear mixed model with linear quantile mixed-effects model, which included cage assignment as a random effect and batch as a covariate, respectively, using package nlme and lgmm in statistical software R

Combining tirzepatide with other interventions Tirzepatide works most effectively as part of comprehensive weight management rather than monotherapy