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Likewise, copper is the cofactor of metabolic enzymes (e.g., cytochrome c oxidase in mitochondria, CuZnSOD in cytosol) and it catalyzes the enzymatic activity of key enzymes of the secretory pathway (reviewed in Polishchuk and Lutsenko, 2013

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These same GST genotypes can also influence autism severityaffecting communication, adaptive skills, and even seizure risk