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NeuroReport 7:18331836 Raps SP, Lai JC, Hertz L, Cooper AJ (1989) Glutathione is present in high concentrations in cultured astrocytes but not in cultured neurons

6.2 NADPH: driving force for glutathione redox cycling The antioxidant activity of glutathione (GSH) critically relies on its regeneration from the oxidized form, glutathione disulfide (GSSG), through a reaction catalyzed by glutathione reductase (GR) that consumes NADPH

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Critically, this redox adaptation is a key mechanism of resistance to radiotherapy and many chemotherapeutic agents, such as cisplatin and doxorubicin, which depend on generating oxidative damage to exert their cytotoxic effects [33]