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(PubMed) Marti-Carvajal AJ, Sola I, Lathyris D, Dayer M
Human clinical trial activity is emerging but limited
This typically reflects the collagen transition phase and should resolve by week six to eight
274,275 This, in turn, diminishes additional downstream effects, including oxidative stress, the secretion of pro-degradative substances, modifications to cell phenotype (hypertrophy, M1/M2 macrophage phenotype, fibrosis), and damage or deterioration of joint cells (apoptosis, senescence)
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