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Hyperglycaemia has been suggested to cause increased expression of inflammation-related genes in macrophages

Obesity is influenced by a variety of factors, including genetics, social determinants of health, and the environment

The trial enrolled 349 Chinese adults with early-stage T2D (duration less than 10 years) and obesity who had inadequate glycemic and weight control after lifestyle intervention with or without metformin monotherapy (mean age: 42.4 years, mean baseline HbA1c: 8.02%, mean baseline body weight: 90.47 kg, mean baseline BMI: 32.98 kg/m2)