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So if you look at exercise, you're up regulating cortisol, obviously chronically is very inflammatory, acutely is necessary for this hormetic effect of we get stronger, right, you stress the bone, obviously we rebuild, regenerate with osteoblast, same thing with the muscle, that's how we develop strength

This underscores the importance of obtaining hormetins from whole foodswhere they exist in naturally moderate concentrationsrather than from high-dose supplements, and it highlights why a deep understanding of the full dose-response curve is essential for both food safety and functional food design

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