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An OA mouse model was successfully established by injecting monosodium iodoacetate (MIA) in mouse knee joints 25 , specifically, involving anesthetic administration with 1.25% tribromoethanol (Bimake, M2920) at a dose of 0.2 mL/10 g body weight, followed by intra-articular injection of 10 L MIA (50 mg/ml, Sigma-Aldrich, 57858-25G-F) into the right knee joint using a 30-gauge needle
This reduction is due to a process called initial recruitment : Some of these primordial follicles go on and develop into primary follicles These primary follicles go on to develop into secondary follicles These secondary follicles die
Ultimately, the decision comes down to individual patient response, treatment goals, and any underlying health conditions
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