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In the last 10 years, two new drug classes have been available for type 2 diabetes therapy, GLP-1 receptor agonists (GLP-1RA) and SGLT-2 inhibitors (SGLT2i)
This is not because KLOW's intrinsic stability changes, but because elimination pathways become temporarily saturated
NAD + also regulates non-redox NAD + -dependent enzymes such as poly-ADP-ribose-polymerases (PARPs) and sirtuins 519
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