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460 Intravenous fasudil markedly reduced sPAP without affecting systemic blood pressure in HAPH patients, demonstrating good tolerability (minor side effects: facial flushing, dry mouth)

It enhances both synthesis and breakdown of extracellular matrix components, such as collagen, glycosaminoglycans (including dermatan and chondroitin sulfate), and decorin, and regulates metalloproteinases and their inhibitors (Pickart, Vasquez-Soltero, and Margolina 2015)

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