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No severe side effects occurred, and there were no signs of fat rebound during the 4-week placebo follow-up

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Understanding these distinctions helps patients and clinicians identify the nature and potential severity of the reaction

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The regulation of peripheral metabolism by gut-derived hormones

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Nanoencapsulation allows the co-delivery of synergistic agents, such as GPX4 inhibitors (RSL3, FIN56), iron donors, and lipid peroxidation amplifiers, at reduced individual doses to circumvent toxicity thresholds and overcome resistance mechanisms [102, 103]

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