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Chronic stress elevates cortisol levels, which can slow digestive motility, alter gut microbiome composition, and increase intestinal permeability

In addition to blocking the receptor sites for catecholamines, third-generation -blockers with associated vasodilating properties, such as carvedilol and nebivolol, provide a broad spectrum of metabolic effects, including anti-inflammatory and antioxidant properties and a favorable impact on glucose and lipid metabolism

Given the importance of these cells in fighting cancer, their exhaustion leads to decreased responsiveness to stimuli, low cytotoxicity, poor IFN- secretion, and thus compromised ability to kill tumour cells (149151)

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