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In summary, M1 macrophages release pro-inflammatory factors that serve a dual function in muscle repair
Antimicrobial activities Antimicrobial mechanism of flavonoids may involve membrane disruption, inhibition of cell envelope synthesis, inhibition of nucleic acid synthesis, inhibition of bacterial virulence and quorum sensing, which impairs their ability to form biofilms, inhibition of efflux pumps, and inhibition of NADH-cytochrome C reductase activity and ATP synthase [39, 40]
Camptothecin (CPT) is a potent anticancer natural compound extracted from the bark of Camptotheca acuminata, which exerts antitumor activity by inhibiting DNA topoisomerase I (Topo I) (Tai et al., 2019)
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