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CAD, coronary artery disease

JAMA 323 , 297299 (2020)

This is how Retatrutide compares to the most effective treatments available today: Semaglutide (found in Wegovy and Ozempic) Objectives: GLP-1 Weight loss average:- 15% Tirzepatide( used in Mounjaro) Objectives:- GLP-1 + GIP Weight Loss Average: 2022% Retatrutide Objectives:- GLP-1 + GIP +Glucagon Weight Loss Average: 24%+ (48 weeks) In clinical trials, retatrutide has shown the greatest weight loss results, sometimes matching the results of bariatric surgery

Camp-mediated signaling promotes the mTOR pathway in beta cells, which induces HIF-1 translational activation