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While early safety data appear favorable, the potential for proangiogenic activity to influence oncogenic processes underscores the importance of comprehensive cancer pre-screening prior to therapeutic use
Murray MF
182,183 Moreover, physcion and its derivative S3, novel small-molecule PGD inhibitors which fits in a pocket of PGD near the binding site of 6-PG to inhibit PGD enzyme activity and then decrease the NADPH level, exhibit excellent anticancer effects and sensitize leukemia cells to antimalarial agent dihydroartemisinin (DHA)
While not harmful, they can be unpleasant and embarrassing
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