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Kenneth McCall, published a paper in 2025 finding that compounded GLP-1s were linked to higher rates of adverse effects than non-compounded products between 2018 and 2024, including more abdominal pain, diarrhea, and nausea

This peptide is engineered to disrupt the interaction between the transcription factor FOXO4 and the tumor suppressor protein p53, a key regulatory pathway involved in senescent cell survival

GLP-1 therapy, often used to aid in weight loss and blood sugar management, works by mimicking the effects of glucagon-like peptide-1 (GLP-1)

Theres been very little human data to show a benefit from unapproved peptides, says Daniel M